Stability of regulatory T-cell lineage.

  title={Stability of regulatory T-cell lineage.},
  author={Shohei Hori},
  journal={Advances in immunology},
Regulatory T (Treg) cells expressing the transcription factor Foxp3 constitute a unique T-cell lineage committed to suppressive functions and play a central role in maintaining self-tolerance and immune homeostasis. While their differentiation state is remarkably stable in the face of various perturbations from the extracellular environment, recent studies have also revealed their adaptability to the changing environment; in response to extrinsic cues, Treg cells differentiate further into… CONTINUE READING

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