Stability of prostaglandin E1 and dinoprostone (prostaglandin E2) under strongly acidic and basic conditions.

Abstract

The stability of prostaglandin E1 and dinoprostone was investigated at the extremes of the pH range (less than or equal to 3 and greater than or equal to 10) in the sequence prostaglandin E leads to prostaglandin A leads to prostaglandin B. The degradation rate is first order with hydrogen-ion and hydroxide-ion concentrations. Separation and analysis of the… (More)

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