Stability of prepulse inhibition and habituation of the startle reflex in schizophrenia: a 6-year follow-up study of initially antipsychotic-naive, first-episode schizophrenia patients.

@article{Hammer2011StabilityOP,
  title={Stability of prepulse inhibition and habituation of the startle reflex in schizophrenia: a 6-year follow-up study of initially antipsychotic-naive, first-episode schizophrenia patients.},
  author={Trine Bj\org Hammer and Bob Oranje and Birgitte Fagerlund and Hannah Bro and Birte Yding Glenth\oj},
  journal={The international journal of neuropsychopharmacology},
  year={2011},
  volume={14 7},
  pages={913-25}
}
Deficits in information processing appear to be core features in the pathogenesis of schizophrenia. Prepulse inhibition (PPI) and habituation of the startle reflex are operational measures of early information processing. Impaired PPI in schizophrenia has been replicated in many studies and is regarded as an endophenotype for schizophrenia. However, reports on the stability of PPI over a longer period of time are lacking, both for patients with schizophrenia and for healthy subjects. The… CONTINUE READING