Stability of omeprazole in an extemporaneously prepared oral liquid.

  title={Stability of omeprazole in an extemporaneously prepared oral liquid.},
  author={Robert A Quercia and Chengde Fan and Xiuwen Liu and Moses Sing Sum Chow},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  volume={54 16},
The stability of omeprazole 2 mg/mL. in an extemporaneously prepared oral liquid was studied. The contents of five 20-mg omeprazole capsules were mixed with 50 mL of 8.4% sodium bicarbonate solution in a Luer-Lok syringe. Three vials of this liquid were prepared for storage at 24, 5, and -20 degrees C. A 3-mL. sample of each was taken initially and on days 1, 2, 3, 4, 6, 8, 10, 12, 14, 18, 22, 26, and 30 and assayed by high-performance liquid chromatography. The liquids stored at 5 degrees C… CONTINUE READING
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