Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic acids in body fluids and tissues.

Abstract

The stability of new compounds with established anticonvulsant activity: picolinic acid 4-pyridyl-methylamide (Pic-4-PMA), cyclopentanecarboxylic acid benzylamide (Cpc-BZA), cycloheptanecarboxylic acid benzylamide (Chc-BZA), picolinic acid 2-fluoro-3-trifluoromethylbenzylamide (Pic-2F-3TFM-BZA), 2-chloronicotinic acid benzylamide (2-Cl-Na-BZA), 6-chloronicotinic acid benzylamide (6-Cl-Na-BZA) and 6-trifluoromethylnicotinic acid benzylamide (6-TFM-Na-BZA) in homogenates of body organs and in body fluids was determined after incubation. It was found that three compounds were stable against enzymes present in body fluids and organs and two were found to decompose in liver and kidney homogenates and two decomposed only in liver homogenate.

Cite this paper

@article{Marszaek2014StabilityON, title={Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic acids in body fluids and tissues.}, author={Dorota Marszałek and Anna Goldnik and Aleksander P. Mazurek and Małgorzata Balicka and Agnieszka Koziorowska and Agnieszka Hermanowicz and Monika Łuka and Milena Piatkowska and Sylwia Grodzka and Sylwia Kumorowska}, journal={Acta poloniae pharmaceutica}, year={2014}, volume={71 2}, pages={261-4} }