Stability of mycophenolic acid and glucuronide metabolites in human plasma and the impact of deproteinization methodology.

@article{Loor2008StabilityOM,
  title={Stability of mycophenolic acid and glucuronide metabolites in human plasma and the impact of deproteinization methodology.},
  author={Henriette de Loor and Maarten Naesens and Kristin Verbeke and Yves F Ch Vanrenterghem and Dirk Kuypers},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2008},
  volume={389 1-2},
  pages={87-92}
}
BACKGROUND In recent years there is growing interest in therapeutic drug monitoring of mycophenolic acid (MPA) and its glucuronide metabolites MPAG and AcMPAG. Like other acyl glucuronide metabolites, AcMPAG has a limited stability, but this aspect has received little attention. METHODS Plasma sample deproteinization with perchloric acid 2 M (method A) was compared to metaphosphoric acid 15% (method B). Stability of MPA, MPAG and AcMPAG in acidified and non-acidified plasma stored at room… CONTINUE READING

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