Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.

@article{AbordoAdesida2005StabilityOL,
  title={Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses.},
  author={Evelyn Abordo-Adesida and Antonia Follenzi and Carlos Barcia and Sandra A. Sciascia and Maria G Castro and Luigi Naldini and Pedro R Lowenstein},
  journal={Human gene therapy},
  year={2005},
  volume={16 6},
  pages={
          741-51
        }
}
Lentiviral vectors are promising tools for gene therapy in the CNS. It is therefore important to characterize their interactions with the immune system in the CNS. This work characterizes transgene expression and brain inflammation in the presence or absence of immune responses generated after systemic immunization with lentiviral vectors. We characterized transduction with SIN-LV vectors in the CNS. A dose-response curve using SIN-LV-GFP demonstrated detectable transgene expression in the… CONTINUE READING

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