Stability of isoniazid, rifampin and pyrazinamide in suspensions used for the treatment of tuberculosis in children

@article{Seifart1991StabilityOI,
  title={Stability of isoniazid, rifampin and pyrazinamide in suspensions used for the treatment of tuberculosis in children},
  author={H. Seifart and D. Parkin},
  journal={The Pediatric Infectious Disease Journal},
  year={1991},
  volume={10},
  pages={827–831}
}
The stability of monosuspensions, consuspensions and multisuspensions of isoniazid (INH), pyrazinamide (PZA) and rifampin (RIF) has been evaluated by high pressure liquid chromatography over a period of 28 days both with and without the addition of vitamin C (20 μg/ml) and at ambient temperatures of 4°C. 24°C and 40°C. At the end of 28 days < 90% of initial concentrations of INH, PZA and RIF in monosuspensions remained unchanged irrespective of ambient temperature as was the case with INH and… Expand
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