Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve.

@article{Fallavollita2001StabilityOH,
  title={Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserve.},
  author={James A. Fallavollita and Michael A Logue and John M. Canty},
  journal={Journal of the American College of Cardiology},
  year={2001},
  volume={37 7},
  pages={1989-95}
}
OBJECTIVES This study was performed to determine whether hibernating myocardium is adaptive or is destined to undergo progressive irreversible injury. BACKGROUND Previous studies have suggested that hibernating myocardium eventually results in progressive dysfunction. Since serial studies cannot be performed in humans, the temporal progression of physiologic and structural adaptations was evaluated in pigs with hibernating myocardium. METHODS Pigs were instrumented with a left anterior… CONTINUE READING