Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate.

@article{DHondt2012StabilityOE,
  title={Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate.},
  author={Matthias D'Hondt and Elien Vangheluwe and Sylvia Van Dorpe and Jente Boonen and Tiene Bauters and Brigitte Pelfrene and Johan Vandenbroucke and Hugo Robays and Bart De Spiegeleer},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2012},
  volume={69 3},
  pages={
          232-40
        }
}
PURPOSE The short-term stability of extemporaneously prepared triple intrathecal therapy, containing cytarabine, methotrexate sodium, and methylprednisolone sodium succinate, was evaluated. METHODS Three batches of triple intrathecal solution were prepared using commercially available products and stored in three different packaging materials (plastic syringe system, brown glass vials, and brown glass vials filled with metal needles). The solutions were protected from light and stored at 5 °C… CONTINUE READING