Stability of essential drugs during shipment to the tropics.

  title={Stability of essential drugs during shipment to the tropics.},
  author={H. Hogerzeil and A. Battersby and V. Srdanovi{\'c} and N. E. Stjernstrom},
  journal={British Medical Journal},
  pages={210 - 212}
OBJECTIVE--To determine whether present methods of international transport of essential drugs by sea adversely affect their quality. DESIGN--Controlled longitudinal study of drug shipments sent by sea from Unicef in Copenhagen to Lagos; to Mombasa and by land to Kampala; and to Bangkok. 11 essential drugs were stored in four locations on board the ships. SETTING--Main shipping routes from Unicef, Copenhagen, to tropical countries. MAIN OUTCOME MEASURES--Temperature and relative humidity in the… Expand
Emergence of Neisseria meningitidis with decreased susceptibility to ciprofloxacin in Argentina.
The stability of essential drugs was not affected during shipment to the tropics after being exposed to much higher temperatures and humidity than recommended by the manufacturer, with temperatures recorded within packs ranging from 23.5 to 42.48C and humidity ranging from 20% to 88%. Expand
The quality and stability of essential drugs in rural Zimbabwe: controlled longitudinal study
A controlled longitudinal study to measure the quality of essential drugs within rural Zimbabwe and to determine whether any failure was due to poor initial quality or to instability of the drugs during inland distribution and storage. Expand
The quality of antimalarials available in Yemen
There are sub-standard antimalarial products circulating within the drug distribution chains in Yemen, which will have serious implications on the reduced therapeutic effectiveness and on the development of drug resistance. Expand
Instability of (methyl)ergometrine in tropical climates: an overview.
In view of the better stability in tropical climates, similar cost, fewer side effects and comparative efficacy, parenteral oxytocin, rather than parenTERal ergometrine, is the drug of choice in the prevention and treatment of postpartum haemorrhage. Expand
The quality of drugs in private pharmacies in the Lao People’s Democratic Republic
Objective: To describe and discuss the quality of a number of sample drugs collected in private pharmacies in Laos (Lao P.D.R.). Design: A stratified random sample was used to select 115 pharmaciesExpand
Assessment of the incidence of substandard drugs in developing countries
Decomposition was the cause of poor quality in a number of samples but overall, poor manufacturing appeared to be prevalent and the analyses generated little evidence to indicate fraudulent manufacturing. Expand
Storage of medicines and temperature control at community pharmacies in rural district of Sindh, Pakistan: an exploratory cross-sectional study
More than a quarter of pharmacy owners were aware about maintaining the required temperature of < 25°C but none of them were maintaining required temperature, considering the electricity shut down. Expand
Variation in Bioavailability of Oral Methylergometrine in Healthy Male Volunteers
This study with oral methylergometrine demonstrated such large interindividual variability in bioavailability that from a pharmacokinetic point of view the oral route of administration does not appear to be the most reliable way for accurate dosing in the prevention of postpartum haemorrhage. Expand
The effect of temperature exposure during shipment on a commercially available demineralized bone matrix putty
Multiple lots of a commercially available demineralized bone matrix (DBM) putty (OsteoSelect® DBM Putty) were subjected to continuous heating at 50 °C, to multiple worst-case temperature spikes, and to multiple freeze–thaw cycles to assess the effects of these temperature extremes on the handling and osteoinductivity of the allograft tissue. Expand
Evaluation of bacteriostatic potency of expired oral paediatric antibiotics and implications on infant health
Preliminary microbiological results on the appreciable reduction in in vitro bacteriostatic potentials, as well as higher resistance and multiple antibiotic resistance rates among expired oral paediatric antibiotics on infantile diarrhoeagenic bacteria are provided. Expand


The shelf life of some antibiotic preparations stored under tropical conditions.
  • P. York
  • Chemistry, Medicine
  • Die Pharmazie
  • 1977
The results indicate the need for stringent control over storage conditions for antibiotic preparations in tropical climates to ensure adequate drug stability and dissolution characteristics. Expand
Kinetics of drug decomposition. Part 62. Kinetics of penicillin G potassium salt (PGP) thermal degradation in solid phase.
The kinetics of degradation of penicillin G K salt (PGP) in solid phase in the temperature range 70-140 degrees C were investigated. The obtained sigmoidal curves were interpreted in terms of theExpand
Thermal Decomposition of Amorphous β-Lactam Antibacterials
Thermal decomposition rates for amorphous samples of penicillin G potassium, cephalothin sodium, cefamandole sodium, and cefamandole nafate were determined as a function of water content andExpand
Kinetics of drug decomposition. Part 61. Kinetics of various ampicillin forms degradation in solid phase.
Ampicillin sodium salt degradation in solid state relies on a sequential reaction consisting of three pseudo first-order processes, and the anhydrous acidic form of ampicillin is very stable in solid phase. Expand
Psychosocial counselling and HIV infection.
Stability at room temperature of medicines normally recommended for cold storage
  • Lancet
  • 1988
Kinetics of drug decomposition . 62 . Kinetics of penicillin G potassium salt ( PGP ) ampicillin trihydrate capsules . ' II We found no stability thermal degradation in solid phase
  • Pol 7 PharmacolPharm
  • 1980
Temperaturebelastung high susceptibility of antibiotics to deterioration in hot von Arzneimitteln an Bord
  • Pharmaceutical Journal