Stability of doxorubicin in relation to chemosensitivity determinations: loss of lethality and retention of antiproliferative activity.

@article{Pavlik1984StabilityOD,
  title={Stability of doxorubicin in relation to chemosensitivity determinations: loss of lethality and retention of antiproliferative activity.},
  author={Edward J Pavlik and Daniel E. Kenady and John Rensselaer van Nagell and Michael B. Hanson and Elvis S. Donaldson and Steve Casper and Douglas Garrett and Daniel Smith and Kathryn Keaton and Robert C. Flanigan},
  journal={Cancer investigation},
  year={1984},
  volume={2 6},
  pages={449-58}
}
The chemical stability of doxorubicin in a variety of tissue culture media has been studied by thin layer chromatography (TLC). In all the media examined, authentic doxorubicin was converted to a chemically distinct form as evidenced by the failure of this form to migrate on TLC plates. The rates of conversion were rapid enough (t 1/2 approximately equal to 3 hr) to be of consequence in chemosensitivity determinations, especially if working solutions of doxorubicin were to be routinely made and… CONTINUE READING