Stability of dendritic spines and synaptic contacts is controlled by αN-catenin

  title={Stability of dendritic spines and synaptic contacts is controlled by αN-catenin},
  author={Kentaro Abe and O. Chisaka and F. Roy and M. Takeichi},
  journal={Nature Neuroscience},
  • Kentaro Abe, O. Chisaka, +1 author M. Takeichi
  • Published 2004
  • Biology
  • Nature Neuroscience
  • Morphological plasticity of dendritic spines and synapses is thought to be crucial for their physiological functions. Here we show that αN-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. In the absence of αN-catenin, spine heads were abnormally motile, actively protruding filopodia from their synaptic contact sites. Conversely, αN-catenin overexpression in dendrites reduced… CONTINUE READING

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