Stability of dendritic spines and synaptic contacts is controlled by αN-catenin

@article{Abe2004StabilityOD,
  title={Stability of dendritic spines and synaptic contacts is controlled by αN-catenin},
  author={Kentaro Abe and Osamu Chisaka and Frans van Roy and Masatoshi Takeichi},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={357-363}
}
Morphological plasticity of dendritic spines and synapses is thought to be crucial for their physiological functions. Here we show that αN-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. In the absence of αN-catenin, spine heads were abnormally motile, actively protruding filopodia from their synaptic contact sites. Conversely, αN-catenin overexpression in dendrites reduced… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…