Stability of dendritic spines and synaptic contacts is controlled by αN-catenin

@article{Abe2004StabilityOD,
  title={Stability of dendritic spines and synaptic contacts is controlled by αN-catenin},
  author={Kentaro Abe and O. Chisaka and F. Roy and M. Takeichi},
  journal={Nature Neuroscience},
  year={2004},
  volume={7},
  pages={357-363}
}
  • Kentaro Abe, O. Chisaka, +1 author M. Takeichi
  • Published 2004
  • Biology
  • Nature Neuroscience
  • Morphological plasticity of dendritic spines and synapses is thought to be crucial for their physiological functions. Here we show that αN-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. In the absence of αN-catenin, spine heads were abnormally motile, actively protruding filopodia from their synaptic contact sites. Conversely, αN-catenin overexpression in dendrites reduced… CONTINUE READING

    Figures from this paper.

    Balancing structure and function at hippocampal dendritic spines.
    • 734
    • Open Access
    Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.
    • 885
    • Open Access
    Dendritic spine dynamics.
    • 307
    • Open Access
    Cell adhesion molecules: signalling functions at the synapse
    • 482
    • Open Access
    Dendritic spines and long-term plasticity
    • 449
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 51 REFERENCES
    Rapid Actin-Based Plasticity in Dendritic Spines
    • 927
    • Open Access
    Actin-based plasticity in dendritic spines.
    • 782
    • Open Access
    Structure and function of dendritic spines.
    • 1,057
    • Open Access