Stability of cyclophosphamide in extemporaneous oral suspensions.

@article{Kennedy2010StabilityOC,
  title={Stability of cyclophosphamide in extemporaneous oral suspensions.},
  author={Rachel H Kennedy and Daniel Groepper and Michael Tagen and Robbin K Christensen and Fariba Navid and Amar Gajjar and Clinton F Stewart},
  journal={The Annals of pharmacotherapy},
  year={2010},
  volume={44 2},
  pages={295-301}
}
BACKGROUND Cyclophosphamide, an alkylating agent, is widely used for the treatment of many adult and pediatric malignancies. The stability of cyclophosphamide in aqueous- and methylcellulose-based oral suspending vehicles is currently unknown. OBJECTIVE To develop and validate a stability-indicating high-performance liquid chromatography (HPLC) method to measure cyclophosphamide concentrations in simple syrup and Ora-Plus, and assess the 56-day chemical stability and physical appearance of… CONTINUE READING