Stability of casein mRNA is ensured by structural interactions between the 3'-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex.

@article{Nagaoka2006StabilityOC,
  title={Stability of casein mRNA is ensured by structural interactions between the 3'-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex.},
  author={Kentaro Nagaoka and Toshiyuki Suzuki and Tomomi Kawano and Kazuhiko Imakawa and Senkiti Sakai},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1759 3-4},
  pages={132-40}
}
The maintenance of mRNA stability has emerged as a mechanism of post-transcriptional control. We demonstrate that beta-casein mRNA stability is dictated by the poly(A) tail and sequences in the 3'-UTR. An in vitro mRNA decay assay revealed that beta-casein mRNA with a long poly(A) tail had higher stability than that with a short poly(A) tail. The addition of poly(A) homopolymer and 3'-UTR cRNA as competitor induced rapid degradation of beta-casein mRNA. The interaction between full-length beta… CONTINUE READING

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