Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.

Abstract

We have identified a case of serous cystadenocarcinoma of the ovary in which the tumor cells display an amplification (from 10- to 20-fold) of the cellular oncogene K-ras. Normal cells purified from the malignant ascites did not show such amplification. Five consecutive samples were obtained by paracentesis over a 9-month period during which the patient received chemotherapy and underwent clinical progression. The level of c-K-ras amplification in the tumor cells did not change during this period. In studies of the tumors of 6 additional patients with adenocarcinoma of the ovary and 5 cell lines of the same histology, we have detected no other example of significant c-K-ras amplification.

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Cite this paper

@article{Filmus1985StabilityOC, title={Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.}, author={Jorge Filmus and Ronald N. Buick}, journal={Cancer research}, year={1985}, volume={45 9}, pages={4468-72} }