Stability of blood phenylalanine levels and IQ in children with phenylketonuria.

  title={Stability of blood phenylalanine levels and IQ in children with phenylketonuria.},
  author={Vera Anastasoaie and Laura Kurzius and Peter G. M. Forbes and Susan L Waisbren},
  journal={Molecular genetics and metabolism},
  volume={95 1-2},
Variability of metabolic control in phenylketonuria (PKU) potentially affects cognitive outcome in early and continuously treated children with this condition. The possibility that homeostasis is more important than the absolute level of exposure to phenylalanine (phe) has not previously been examined. A meta-analysis of 40 studies showed that in children with phenylketonuria (PKU), mean lifetime blood phe levels were significantly correlated with Full Scale IQ (FSIQ) (r=-0.34). A similar… CONTINUE READING

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