Stability of anthracycline antitumor agents in four infusion fluids.

  title={Stability of anthracycline antitumor agents in four infusion fluids.},
  author={Guiragos K. Poochikian and James C. Cradock and Karl P. Flora},
  journal={American journal of hospital pharmacy},
  volume={38 4},
The stabilities of doxorubicin hydrochloride, daunorubicin hydrochloride, zorubicin, and aclacinomycin A hydrochloride were studied in various infusion fluids at ambient temperature. Reversed-phase high-pressure liquid chromatographic procedures developed and used in these studies employed internal standards and readily separated each drug from its degradation products. Dilute solutions of the anthracyclines were prepared by appropriate dilutions of the reconstituted solutions of the formulated… CONTINUE READING