Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice

@article{Bingham1995StabilityOA,
  title={Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice},
  author={Peter M. Bingham and Marion Oronzi Scott and Suping Wang and Michael J. McPhaul and Elizabeth M. Wilson and James Y. Garbern and Diane E. Merry and Kenneth H. Fischbeck},
  journal={Nature Genetics},
  year={1995},
  volume={9},
  pages={191-196}
}
The expansion of trinucleotide repeat sequences underlies a number of hereditary neurological disorders. To study the stability of a trinucleotide repeat and to develop an animal model of one of these disorders, spinal and bulbar muscular atrophy (SBMA), we have generated transgenic mice carrying either the normal or expanded repeat human androgen receptor (AR) gene. Unlike the disease allele in humans, the AR cDNA containing the expanded repeat in transgenic mice showed no change in repeat… CONTINUE READING