Stability of a surface-bound oligonucleotide duplex inferred from molecular dynamics: a study of single nucleotide defects using DNA microarrays.

@article{Naiser2009StabilityOA,
  title={Stability of a surface-bound oligonucleotide duplex inferred from molecular dynamics: a study of single nucleotide defects using DNA microarrays.},
  author={Thomas Naiser and Jona Kayser and Timo Mai and Wolfgang Michel and Albrecht Ott},
  journal={Physical review letters},
  year={2009},
  volume={102 21},
  pages={218301}
}
Microarray technology uses the sequence dependent hybridization (binding) affinity of surface-bound oligonucleotide strands for the quantification of complex nucleic acid mixtures. In spite of its huge potential in life science and medicine, microarray oligonucleotide hybridization remains far from being understood. Taking advantage of microarray combinatorial possibilities we show that, although surface bound, the hybridization affinities of single-base mismatched oligonucleotides can be… CONTINUE READING
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