Stability of Rearrangement Measures in the Comparison of Genome Sequences

  title={Stability of Rearrangement Measures in the Comparison of Genome Sequences},
  author={David Sankoff and Matthew Mazowita},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={13 2},
We present data-analytic and statistical tools for studying rates of rearrangement of whole genomes and to assess the stability of these methods with changes in the level of resolution of the genomic data. We construct datasets on the numbers of conserved syntenies and conserved segments shared by pairs of animal genomes at different levels of resolution. We fit these data to an evolutionary tree and find the rates of rearrangement on various evolutionary lineages. We document the lack of… CONTINUE READING
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