Stability of Insertion Sequences in Mycobacterium tuberculosis Complex Strains: Evaluation of an Insertion Sequence-Dependent DNA Polymorphism as a Tool in the Epidemiology of Tuberculosis


In this study we established the usefulness ofDNA fingerprinting for the epidemiology of tuberculosis on the basis of the DNA polymorphism generated by the insertion sequence (IS) IS986. Although clinical isolates of Mycobacterium tuberculosis displayed a remarkably high degree of restriction fragment length polymorphism, we showed that transposition of… (More)


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