Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years.

  title={Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years.},
  author={Xuejun Hao and Ardesheer Talati and Stewart A Shankman and Jun Liu and Jurgen Kaiser and Craig E. Tenke and Virginia Warner and David P. Semanek and P. A. J. N. Wickramaratne and Myrna M. Weissman and Jonathan E Posner},
  journal={Biological psychiatry. Cognitive neuroscience and neuroimaging},
  volume={2 7},
BACKGROUND A biological marker of vulnerability should precede onset of illness and be independent of disease course. We previously reported that cortical thinning may serve as a potential biomarker for risk for familial depression. We now test stability of the cortical thinning across 8 years, and whether thinning mediates associations between familial risk and depressive traits. METHOD Participants were from a 3-generation family study of depression, where 2nd and 3rd generation offspring… CONTINUE READING
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