Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

@article{Na2007StabilityOA,
  title={Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity},
  author={Dong Hee Na and Jabar Faraj and Yilmaz Çapan and Kai P. Leung and Patrick P Deluca},
  journal={Pharmaceutical Research},
  year={2007},
  volume={24},
  pages={1544-1550}
}
To investigate the stability of KSL, an antimicrobial decapeptide, and its analogues, in human saliva and simulated gastric fluid for delivery in the oral cavity. The degradation products of KSL in human saliva and simulated gastric fluid were separated by reversed-phase HPLC and their structures were identified by electrospray ionization-mass spectrometry. Analogues of KSL were synthesized by solid-phase synthesis procedure. Their enzymatic stabilities and antimicrobial activities were studied… CONTINUE READING
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