Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

@article{Na2007StabilityOA,
  title={Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity},
  author={Dong Hee Na and J. Faraj and Y. Capan and Kai P. Leung and Patrick P. DeLuca},
  journal={Pharmaceutical Research},
  year={2007},
  volume={24},
  pages={1544-1550}
}
  • Dong Hee Na, J. Faraj, +2 authors Patrick P. DeLuca
  • Published 2007
  • Chemistry, Medicine
  • Pharmaceutical Research
  • PurposeTo investigate the stability of KSL, an antimicrobial decapeptide, and its analogues, in human saliva and simulated gastric fluid for delivery in the oral cavity.Materials and MethodsThe degradation products of KSL in human saliva and simulated gastric fluid were separated by reversed-phase HPLC and their structures were identified by electrospray ionization-mass spectrometry. Analogues of KSL were synthesized by solid-phase synthesis procedure. Their enzymatic stabilities and… CONTINUE READING
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