Stability of (2'-5')oligoriboadenylates in various sera.

  title={Stability of (2'-5')oligoriboadenylates in various sera.},
  author={{\vS}tefan Vil{\vc}ek and O. J. Vrtiak and J. Smrt and M. Jurov{\vc}{\'i}k},
  journal={FEBS letters},
  volume={166 2},
Avian and mammalian sera were found to contain an enzyme activity degrading 2-5A oligonucleotides. The most extensive degradation of the A2' p5' A was observed in chicken serum. Degradation of this compound is not affected by the presence of cAMP, dsRNA, Mg2+, but is significantly inhibited by EDTA. The enzyme activity described is not inactivated by heating to 56 degrees C for 30 min. The 5-mU3' p5' A has also been degraded in chicken serum.