Stability determination of solid lipid nanoparticles (SLN) in aqueous dispersion after addition of electrolyte.

@article{Freitas1999StabilityDO,
  title={Stability determination of solid lipid nanoparticles (SLN) in aqueous dispersion after addition of electrolyte.},
  author={C Freitas and Rainer Helmut Mueller},
  journal={Journal of microencapsulation},
  year={1999},
  volume={16 1},
  pages={
          59-71
        }
}
The contribution of mono-, di- and trivalent ions to the destabilization of solid lipid nanoparticle (SLN) dispersions was investigated, i.e. particle growth and subsequent formation of semi-solid gels. Sodium, calcium and aluminium chloride were added in varying concentrations to a Compritol formulation which had proved to be highly sensitive towards destabilizing effects. Dispersions containing up to 10(-3) M sodium chloride remained stable for 14 days. The same concentrations of calcium or… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Advances in lipid-based drug delivery: enhancing efficiency for hydrophobic drugs.

  • Expert opinion on drug delivery
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND