Stability changes in pim-1 proto-oncogene mRNA after mitogen stimulation of normal lymphocytes.

@article{Wingett1991StabilityCI,
  title={Stability changes in pim-1 proto-oncogene mRNA after mitogen stimulation of normal lymphocytes.},
  author={Denise G Wingett and Raymond Reeves and Nancy S. Magnuson},
  journal={Journal of immunology},
  year={1991},
  volume={147 10},
  pages={3653-9}
}
mRNA expression of the serine/threonine kinase protooncogene Pim-1 was investigated in mitogen-treated normal bovine lymphocytes. After stimulation with Con A and phorbol ester (PMA), normal bovine PBMC exhibited a 3.5-fold induction of pim-1 mRNA within 4 h of stimulation. By 17 h poststimulation, however, the level of pim-1 mRNA had fallen to approximately 50%. Similar transient kinetics of pim-1 expression were also observed in mitogen-stimulated bovine lymph node lymphocytes and the amount… CONTINUE READING

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