Stability and stoichiometry of bilayer phospholipid-cholesterol complexes: relationship to cellular sterol distribution and homeostasis.

@article{Lange2013StabilityAS,
  title={Stability and stoichiometry of bilayer phospholipid-cholesterol complexes: relationship to cellular sterol distribution and homeostasis.},
  author={Yvonne Lange and S. M. Ali Tabei and Jin Ye and T. Steck},
  journal={Biochemistry},
  year={2013},
  volume={52 40},
  pages={
          6950-9
        }
}
Is cholesterol distributed among intracellular compartments by passive equilibration down its chemical gradient? If so, its distribution should reflect the relative cholesterol affinity of the constituent membrane phospholipids as well as their capacity for association with the sterol. We examined this issue by analyzing the reactivity to cholesterol oxidase of large unilamellar vesicles (LUVs) containing phospholipids and varied levels of cholesterol. The rates of cholesterol oxidation… CONTINUE READING
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