Stability and sterility of recombinant tissue plasminogen activator at -30 degrees C.

@article{Wiernikowski2000StabilityAS,
  title={Stability and sterility of recombinant tissue plasminogen activator at -30 degrees C.},
  author={John T Wiernikowski and Mark Crowther and Catherine M. Clase and Angela Ingram and Maureen Andrew and Alice Y. K. Chan},
  journal={Lancet},
  year={2000},
  volume={355 9222},
  pages={2221-2}
}
We assessed whether frozen recombinant tissue plasminogen activator (rt-PA) remains stable and sterile for up to 22 weeks at -30 degrees C. Our findings confirm that rt-PA is a cost-effective alternative to urokinase for restoring patency to occluded central venous catheters. 

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