Stability and robustness of an organelle number control system: modeling and measuring homeostatic regulation of centriole abundance.

Control of organelle abundance is a fundamental unsolved problem in cell biology. Mechanisms for number control have been proposed in which organelle assembly is actively increased or decreased to compensate for deviations from a set-point, but such phenomena have not been experimentally verified. In this report we examine the control of centriole copy… CONTINUE READING