Stability and perfusion studies of Desmopressin (dDAVP) and prodrugs in the rat jejunum.

@article{Lepist1999StabilityAP,
  title={Stability and perfusion studies of Desmopressin (dDAVP) and prodrugs in the rat jejunum.},
  author={Eve Irene Lepist and Jesper Ostergaard and Karin Fredholt and Hans Lennernaes and Gitte Juel Friis},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={1999},
  volume={51 4-5},
  pages={363-8}
}
Three aliphatic carboxylic acid esters of the tyrosine phenolic group in Desmopressin (dDAVP) were investigated in vitro for their stability and metabolism in rat gastrointestinal media. The degradation followed strictly first-order kinetics and the prodrugs were quantitatively converted to dDAVP. The n-hexanoyl (II) and n-octanoyl (III) esters were rapidly hydrolysed in 10% rat jejunal fluid showing half-lives of 1.1+/-0.2 min and 1.4+/-0.1 min, respectively. In 5 % rat jejunal homogenate the… CONTINUE READING