Stability and neutralization capacity of a novel mosaic HIV-1 gp140 trimer in a guinea pig model


Background The generation of globally relevant HIV-1 immunogens mimicking native, trimeric Envelope (Env) structure, remains a major challenge for HIV-1 vaccine development. We identified a mosaic Env sequence, originally designed to optimize cellular immunologic coverage of global HIV-1 sequence diversity, which was capable of forming biochemically stable… (More)
DOI: 10.1186/1742-4690-9-S2-P299


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