Stability and immunogenicity properties of the gene-silencing polypurine reverse Hoogsteen hairpins.

@article{Villalobos2014StabilityAI,
  title={Stability and immunogenicity properties of the gene-silencing polypurine reverse Hoogsteen hairpins.},
  author={Xenia Villalobos and Laura Bermejo Rodr{\'i}guez and Jeanne Pr{\'e}vot and Carlota Oleaga and Carlos Ciudad and V{\'e}ronique No{\'e}},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 1},
  pages={
          254-64
        }
}
Gene silencing by either small-interference RNAs (siRNA) or antisense oligodeoxynucleotides (aODN) is widely used in biomedical research. However, their use as therapeutic agents is hindered by two important limitations: their low stability and the activation of the innate immune response. Recently, we developed a new type of molecule to decrease gene expression named polypurine reverse Hoogsteen hairpins (PPRHs) that bind to polypyrimidine targets in the DNA. Herein, stability experiments… CONTINUE READING
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