Stability and function of secondary Th1 memory cells are dependent on the nature of the secondary stimulus.

@article{Kim2012StabilityAF,
  title={Stability and function of secondary Th1 memory cells are dependent on the nature of the secondary stimulus.},
  author={Chulwoo Kim and David C. Jay and Matthew A Williams},
  journal={Journal of immunology},
  year={2012},
  volume={189 5},
  pages={2348-55}
}
Following acute infection in some mouse models, CD4+ memory T cells steadily decline over time. Conversely, in humans, CD4+ memory T cells can be maintained for many years at levels similar to CD8+ T cells. Because we previously observed that the longevity of Th1 memory cell survival corresponded to their functional avidity, we hypothesized that secondary challenge, which enriches for high functional avidity Th1 responders, would result in more stable Th1 memory populations. We found that… CONTINUE READING