Stability and flexibility of epigenetic gene regulation in mammalian development

@article{Reik2007StabilityAF,
  title={Stability and flexibility of epigenetic gene regulation in mammalian development},
  author={Wolf Reik},
  journal={Nature},
  year={2007},
  volume={447},
  pages={425-432}
}
  • W. Reik
  • Published 24 May 2007
  • Biology
  • Nature
During development, cells start in a pluripotent state, from which they can differentiate into many cell types, and progressively develop a narrower potential. Their gene-expression programmes become more defined, restricted and, potentially, 'locked in'. Pluripotent stem cells express genes that encode a set of core transcription factors, while genes that are required later in development are repressed by histone marks, which confer short-term, and therefore flexible, epigenetic silencing. By… 
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