Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient

  title={Stability and Nuclear Dynamics of the Bicoid Morphogen Gradient},
  author={Thomas Gregor and Eric F. Wieschaus and Alistair P McGregor and William Bialek and David W. Tank},
Patterning in multicellular organisms results from spatial gradients in morphogen concentration, but the dynamics of these gradients remain largely unexplored. We characterize, through in vivo optical imaging, the development and stability of the Bicoid morphogen gradient in Drosophila embryos that express a Bicoid-eGFP fusion protein. The gradient is established rapidly (approximately 1 hr after fertilization), with nuclear Bicoid concentration rising and falling during mitosis. Interphase… CONTINUE READING
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