Stability, miscoding potential, and repair of 2'-deoxyxanthosine in DNA: implications for nitric oxide-induced mutagenesis.

@article{Wuenschell2003StabilityMP,
  title={Stability, miscoding potential, and repair of 2'-deoxyxanthosine in DNA: implications for nitric oxide-induced mutagenesis.},
  author={Gerald E. Wuenschell and Timothy R. O'Connor and John S Termini},
  journal={Biochemistry},
  year={2003},
  volume={42 12},
  pages={
          3608-16
        }
}
Nitric oxide (NO(*)) reacts with guanine in DNA and RNA to produce xanthine (X) as a major product. Despite its potential importance in NO(*)-mediated mutagenesis, the biochemical properties of X in polynucleotides have been relatively unexplored. We describe the synthesis and chemical characterization of xanthine-containing oligonucleotides and report on the susceptibility of X to depurination, its miscoding potential during replication by polymerases, and its recognition and excision by… CONTINUE READING
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