Stability, Flexibility, and Dynamic Interactions of Colliding RNA Polymerase II Elongation Complexes

@inproceedings{Saeki2009StabilityFA,
  title={Stability, Flexibility, and Dynamic Interactions of Colliding RNA Polymerase II Elongation Complexes},
  author={Hideaki Saeki and Jesper Q. Svejstrup},
  booktitle={Molecular cell},
  year={2009}
}
  • Hideaki Saeki, Jesper Q. Svejstrup
  • Published in Molecular cell 2009
  • Biology, Medicine
  • Multiple RNA polymerase II (RNAPII) molecules can transcribe a gene simultaneously, but what happens when such polymerases collide--for example due to polymerase pausing or DNA damage? Here, RNAPII collision was characterized using a reconstituted system for simultaneous transcription by two polymerases. When progression of leading polymerase is obstructed, rear-end collision entails a transient state in which the elongation complexes interact, followed by substantial backtracking of trailing… CONTINUE READING

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