St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse.

@article{Bray2002StJW,
  title={St. John's wort extract induces CYP3A and CYP2E1 in the Swiss Webster mouse.},
  author={B. Bray and Nigel B Perry and David B Menkes and Rhonda J. Rosengren},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={66 1},
  pages={27-33}
}
This investigation was designed to determine the ability of St. John's wort (SJW), a readily available antidepressant, to induce various hepatic drug metabolizing enzymes. SJW (140 or 280 mg/kg/day) was administered to male Swiss Webster mice for 1, 2, or 3 weeks. Enzymatic activity was analyzed in hepatic microsomes for all of the following drug metabolizing enzymes: CYP3A, CYP1A, CYP2E1, and UDP-glucuronosyltransferase (UDPGT). The catalytic activity of CYP1A was unchanged from control… CONTINUE READING