St Johns wort increases expression of P-glycoprotein: implications for drug interactions.

@article{Hennessy2002StJW,
  title={St Johns wort increases expression of P-glycoprotein: implications for drug interactions.},
  author={Martina Hennessy and D. Kelleher and James Paul Spiers and Michelle Barry and Pierce V Kavanagh and David J. Back and F. David Mulcahy and John Feely},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={53 1},
  pages={
          75-82
        }
}
AIMS St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs. Co-administration with SJW has resulted in significant reductions in trough plasma concentrations of indinavir and cyclosporin [1, 2]. Induction of cytochrome P450 3A4 (CYP3A4) has been implicated as the most likely interaction mechanism. However, the magnitude of the interaction seen in clinical practice is greater than that predicted by in… CONTINUE READING

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