St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response

@article{Wong2004StJW,
  title={St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response},
  author={M -L Wong and Fiona O'Kirwan and Jonas Hannestad and Kristopher J. L. Irizarry and David Elashoff and Julio Licinio},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={237-251}
}
Both the prototypic tricyclic antidepressant imipramine (IMI) and the herbal product St John's wort (SJW) can be effective in the treatment of major depressive disorder. We studied hypothalamic gene expression in rats treated with SJW or IMI to test the hypothesis that chronic antidepressant treatment by various classes of drugs results in shared patterns of gene expression that may underlie their therapeutic effects. Individual hypothalami were hybridized to individual Affymetrix chips; we… CONTINUE READING

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