SslE (YghJ), a cell associated and secreted lipoprotein of neonatal septicemic E. coli induces TLR2 dependent macrophage activation and proinflammation through NFκB and MAP kinase signaling.

SslE (YghJ), a cell surface associated and secreted lipoprotein was identified as a potential vaccine candidate for extraintestinal pathogenic E. coli providing nearly complete protection from sepsis in a mouse model. We earlier found that SslE from neonatal septicemic E. coli could trigger the secretion of various proinflammatory cytokines in murine… CONTINUE READING