Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA.

@article{Kim2012Srs2PA,
  title={Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA.},
  author={Seong Ok Kim and Hyerim Yoon and Seong Oak Park and Miju Lee and Jae-Sun Shin and Kyoung-Seok Ryu and J Lee and Y Seo and Hyun Suk Jung and Byong-Seok Choi},
  journal={Journal of molecular cell biology},
  year={2012},
  volume={4 4},
  pages={258-61}
}
Dear Editor, The modification of proliferating cell nuclear antigen (PCNA) by small ubiquitinlike modifier (SUMO) recruits Srs2 during S phase (Hoege et al., 2002; Pfander et al., 2005). The recruitment of Srs2 to replication fork through physical interaction between the C-terminus of Srs2 (residues 1038–1174) and SUMOylated PCNA regulates homologous recombination by disrupting the Rad51 nucleoprotein filament formation, which is an essential step in a recombination pathway (Krejci et al., 2003… CONTINUE READING