Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation.

@article{Weinhold2000SrfEC,
  title={Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation.},
  author={Birgit Weinhold and Gerhard Schratt and Sergei Arsenian and Jennifer Berger and Kenji Kamino and Heinz J. Schwarz and Ulrich U R{\"u}ther and Alfred Nordheim},
  journal={The EMBO journal},
  year={2000},
  volume={19 21},
  pages={
          5835-44
        }
}
The serum response factor (SRF) transcription factor is essential for murine embryogenesis. SRF+(-/-) embryos stop developing at the onset of gastrulation, lacking detectable mesoderm. This developmental defect may reflect cell-autonomous impairment of SRF(-/-) embryonic cells in mesoderm formation. Alternatively, it may be caused by a non-cell-autonomous defect superimposed upon inappropriate provision of mesoderm-inducing signals to primitive ectodermal cells. We demonstrate that the ability… CONTINUE READING
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