Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans.

@article{Chang2007Sre1pAR,
  title={Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans.},
  author={Yun C. Chang and Clara M. Bien and Hyeseung Lee and Peter J. Espenshade and Kyung J. Kwon-Chung},
  journal={Molecular microbiology},
  year={2007},
  volume={64 3},
  pages={614-29}
}
Cryptococcus neoformans is an environmental pathogen requiring atmospheric levels of oxygen for optimal growth. Upon inhalation, C. neoformans disseminates to the brain and causes meningoencephalitis, but the mechanisms by which the pathogen adapts to the low-oxygen environment in the brain have not been investigated. We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway. Low oxygen decreased sterol synthesis… CONTINUE READING
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