Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53.

@article{Zhao2009SrcasmIF,
  title={Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53.},
  author={Liang Zhao and Weijie Li and Christine Marshall and Thomas Griffin and Matthew E. Hanson and Ryan W Hick and Tzvete Dentchev and Erik A Williams and Adrienne Werth and Christopher P Miller and Hasan M. Bashir and Warren S Pear and John T Seykora},
  journal={Cancer research},
  year={2009},
  volume={69 24},
  pages={9439-47}
}
Src family tyrosine kinases (SFK) regulate cell proliferation, and increased SFK activity is common in human carcinomas, including cutaneous squamous cell carcinomas (SCC) and its precursors. The elevated SFK activity in cutaneous SCCs was modeled using K14-Fyn Y528F transgenic mice, which spontaneously form punctate keratotic lesions, scaly plaques, and large tumors resembling actinic keratoses, SCC in situ, and SCCs, respectively. Lesional tissue showed increased levels of activated SFKs… CONTINUE READING
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Overexpression of a constitutively active form of c-src in skin epi9447

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