Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.

@article{Chao1997SrcTK,
  title={Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.},
  author={T S Chao and Mark K Abe and Marc Hershenson and Ivone Gomes and Marsha Rich Rosner},
  journal={Cancer research},
  year={1997},
  volume={57 15},
  pages={3168-73}
}
Thapsigargin is a non-phorbol ester-type tumor promoter that elevates the intracellular Ca2+ (Ca(i)2+) levels by blocking the microsomal Ca2+ ATPase. At present, the consequence of this Ca(i)2+ increase and the nature of the tumorigenicity of thapsigargin still remain to be elucidated. Previously, we demonstrated that thapsigargin activates the mitogen… CONTINUE READING