Src tyrosine kinase inhibition prevents pulmonary ischemia–reperfusion-induced acute lung injury

@article{Oyaizu2012SrcTK,
  title={Src tyrosine kinase inhibition prevents pulmonary ischemia–reperfusion-induced acute lung injury},
  author={Takeshi Oyaizu and Shan-Yu Fung and Atsushi Shiozaki and Zehong Guan and Qiao Zhang and Claudia C. Dos Santos and Bing Han and Marco Mura and Shaf H Keshavjee and Mingyao Liu},
  journal={Intensive Care Medicine},
  year={2012},
  volume={38},
  pages={894-905}
}
Pulmonary ischemia–reperfusion is a pathological process seen in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation for circulatory arrest, atherosclerosis, and pulmonary embolism. A better understanding of its molecular mechanisms is very important. Rat left lung underwent in situ ischemia for 60 min, followed by 2 h of reperfusion. The gene expression profiles and Src protein tyrosine kinase (PTK) phosphorylation were studied over time, and PP2… CONTINUE READING

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