Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area.

@article{Schumann2009SrcproteinTK,
  title={Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area.},
  author={Johanna Schumann and Avner Michaeli and Rami Yaka},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 3},
  pages={
          697-706
        }
}
  • Johanna Schumann, Avner Michaeli, Rami Yaka
  • Published in Journal of neurochemistry 2009
  • Medicine, Biology
  • Cocaine-induced long-term potentiation of glutamatergic synapses in the ventral tegmental area (VTA) has been proposed as a key process that contributes to the development of addictive behaviors. In particular, the activation of ionotrophic glutamate NMDA receptor (NMDAR) in the VTA is critical for the initiation of cocaine sensitization. Here we show that application of cocaine both in slices and in vivo induced an increase in tyrosine phosphorylation of the NR2A, but not the NR2B subunit of… CONTINUE READING

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