Src promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling

@inproceedings{ArcherLahlou2009SrcPD,
  title={Src promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling},
  author={Elodie Archer-Lahlou and Nicolas Audet and Mohammad Gholi Amraei and Karine Huard and M{\'e}lanie Paquin-Gobeil and Graciela Pi{\~n}eyro},
  booktitle={Journal of cellular and molecular medicine},
  year={2009}
}
Abstract An important limitation in the clinical use of opiates is progressive loss of analgesic efficacy over time. Development of analgesic tolerance is tightly linked to receptor desensitization. In the case of delta opioid receptors (DOR), desensitization is especially swift because receptors are rapidly internalized and are poorly recycled to the membrane. In the present study, we investigated whether Src activity contributed to this sorting pattern and to functional desensitization of… CONTINUE READING
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Beta 1/beta 2-adrenergic

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